Document Detail


Leuconostoc bacteremia in pediatric patients with short bowel syndrome: case series and review.
MedLine Citation:
PMID:  18833028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Infections caused by Leuconostoc species are rare with most reported cases occurring in immunocompromised patients. This article presents 6 new cases of pediatric patients with short bowel syndrome who developed Leuconostoc bacteremia, and compares these cases with those previously reported in the literature. MATERIALS AND METHODS: This is a retrospective, descriptive study (January 2001 to May 2007) performed in a tertiary care teaching center. Hospitalized patients younger than 18 years of age, with multiple positive blood cultures for Leuconostoc spp. were evaluated. The collected data were compared with 10 similar previously reported cases. RESULTS: Six new cases of pediatric patients with short bowel syndrome who developed Leuconostoc bacteremia were identified. All 6 patients had received total parenteral nutrition and had central venous access, while 3 of these patients also received enteral nutrition. These results are similar to those reported in the literature. Only one of the newly reported patients had received vancomycin therapy before detection of Leuconostoc in the blood, whereas all prior reported cases had previously received this antimicrobial agent. Molecular analysis identified Leuconostoc mesenteroides as the most common species (4 cases) detected. CONCLUSIONS: This report expands on the number of cases of Leuconostoc bacteremia in pediatric patients with short bowel syndrome and shows that prior vancomycin is not a required risk factor for the development of this infection. As previously reported in the literature, the presence of a central venous catheter and disrupted bowel mucosa are risk factors for Leuconostoc bacteremia.
Authors:
Diana Florescu; Lisa Hill; Debra Sudan; Peter C Iwen
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  27     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-28     Completed Date:  2008-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1013-9     Citation Subset:  IM    
Affiliation:
Immunocompromised Host Infectious Diseases Program, Microbiology University of Nebraska Medical Center, Omaha, NE, USA. dflorescu@unmc.edu
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / therapeutic use
Bacteremia / diagnosis,  drug therapy,  etiology*
Catheters, Indwelling / adverse effects,  microbiology
Child
Child, Preschool
Enteral Nutrition
Female
Gentamicins / therapeutic use
Gram-Positive Bacterial Infections / diagnosis,  drug therapy,  etiology*
Humans
Infant
Infant, Newborn
Leuconostoc / drug effects,  genetics,  isolation & purification
Male
Parenteral Nutrition, Total
Penicillin G / therapeutic use
Polymerase Chain Reaction
Retrospective Studies
Risk Factors
Sequence Analysis, DNA
Short Bowel Syndrome / complications*
Vancomycin / therapeutic use
Vancomycin Resistance
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins; 1404-90-6/Vancomycin; 61-33-6/Penicillin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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