Document Detail


Leucocytosis, thrombocytosis, and plasma osmolality during rest and exercise: an hypothesis.
MedLine Citation:
PMID:  10424721     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism for inducing leucocytosis (increase in white blood cells) and thrombocytosis (increase in platelets) during exercise is unclear. Because plasma osmolality (Osm) may influence T-cell proliferation, Osm and the number of leucocytes (WBC) and platelets in blood were measured periodically during a 90 min rest period, and were compared with those during upright sitting ergometer exercise in six untrained, healthy men who cycled for 70 min at 71% of their maximal oxygen uptake (VO2max). There were 6 experiments in which the subjects drank different fluid formulations (10 ml x kg(-1) of various ionic and osmotic concentrations intermittently during 60 min of the rest period and during the exercise period. Osmolality, and WBC and platelet counts increased significantly (p < 0.05) within the first 10 min of exercise, but the additional 60 min of exercise did not significantly change the leucocytosis or thrombocytosis. There were low but significant correlations between individual values of total WBC and total Osm during exercise (r0.001(2),284 = 0.39) and during rest plus exercise (r0.001(2),499 = 0.43). With combined data from the six experiments, mean Osm correlated highly and significantly with both mean WBC (r0.001(2),6 = 0.95, p < 0.001) and mean platelets (r0.001(2),6 = 0.94, p < 0.01) during the exercise phase. These data indicate that increases in leucocytes, thrombocytes, and osmolality occur primarily within the first 10 min of high-intensity exercise, but neither hypovolemia nor hyperthermia during exercise contributed to the leucocytosis, thrombocytosis, or hyperosmolality. The high correlations between plasma Osm and WBC or platelet counts suggest changes in osmolality may contribute to the mechanism of leucocytosis and thrombocytosis induced by exercise.
Authors:
M A McKenzie; J E Greenleaf; R Looft-Wilson; P R Barnes
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  50     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-09-22     Completed Date:  1999-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  259-73     Citation Subset:  IM; S    
Affiliation:
Laboratory for Human Environmental Physiology, Gravitational Research Branch, NASA Ames Research Center, Moffett Field, CA 94035-1000, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Platelets / physiology
Body Temperature / physiology
Body Weight / physiology
Drinking / physiology
Exercise / physiology*
Humans
Leukocytes / physiology
Leukocytosis / blood,  etiology,  physiopathology*,  urine
Male
Osmolar Concentration
Plasma Volume / physiology*
Rest / physiology
Thrombocytosis / blood,  etiology,  physiopathology*,  urine
Investigator
Investigator/Affiliation:
J E Greenleaf / ARC; R Looft-Wilson / U IA, Iowa City

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