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Leucocytoclastic vasculitis in severe ulcerative colitis.
MedLine Citation:
PMID:  21634306     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Ulcerative colitis may be associated with a number of extraintestinal skin manifestations including erythema nodosum and pyoderma gangrenosum. We describe an unusual case of a 26-year-old military pilot with ulcerative colitis and skin lesions diagnosed as leucocytoclastic vasculitis. The skin lesions occurred twice during the severe flare. The first occurrence was treated successfully with corticosteroids. When the lesions recurred several weeks later, concomitant with the ongoing flare, treatment with mesalamine and infliximab resolved the lesions. Ultimately, the patient required total colectomy for flare unresponsive to maximum medical therapy. The leucocytoclastic vasculitis did not recur after colectomy. We propose a potential immunopathophysiologic mechanism linking the 2 conditions based on recent biochemical and clinical research.
Authors:
Donald Martin; Tristan Handler; Joseph McDermott
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Military medicine     Volume:  176     ISSN:  0026-4075     ISO Abbreviation:  Mil Med     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-06-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984771R     Medline TA:  Mil Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-3     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, 48 MDOS/SGOMI, Unit 5210 Box 320, RAF Lakenheath, Brandon, Suffolk IP27 9PN, United Kingdom.
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