Document Detail

Leucocyte mobilization and function in vitro of blood and exudative leucocytes after inguinal herniotomy.
MedLine Citation:
PMID:  6751461     Owner:  NLM     Status:  MEDLINE    
The effect of surgical trauma on leucocyte mobilization in vivo and the function of blood and exudative leucocytes was studied in 15 patients after inguinal herniotomy. Mobilization of leucocytes to skin windows with chambers was reduced 48 h after anaesthesia (P less than 0.01) compared with 21 healthy volunteers. Blood leucocyte chemotaxis was reduced during the period of anaesthesia (P less than 0.05). Serum independent phagocytosis was increased from 24 h after anaesthesia (P less than 0.01) but without a corresponding increase in the serum dependent phagocytosis. The oxidative metabolic activity of resting leucocytes in terms of Nitro Blue Tetrazolium (NBT) reduction decreased 24-48 h after anaesthesia without any change in NBT reduction during phagocytosis. In contrast, exudative leucocytes exhibited reduced phagocytosis independent of serum factors (P less than 0.05) and increased NBT reduction by resting leucocytes. It is concluded that a diminished accumulation of leucocytes as inflammatory lesions occurs postoperatively and that changes in the function of circulating leucocytes do not always reflect the changes in function of the exudative leucocyte.
J H Wandall
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  69     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1982-12-21     Completed Date:  1982-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  669-72     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Migration Inhibition
Exudates and Transudates / cytology
Hernia, Inguinal / immunology,  surgery*
Leukocytes / immunology*
Middle Aged
Neutrophils / immunology
Skin Window Technique

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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