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Leucocyte count in young adults with first-ever ischaemic stroke: associated factors and association on prognosis.
MedLine Citation:
PMID:  23295074     Owner:  NLM     Status:  Publisher    
BACKGROUND: Limited data exist on the associated factors and correlation of leucocyte count to outcome in young adults with first-ever ischaemic stroke. AIMS: Our objectives were to investigate factors associated with elevated leucocyte count and whether there is correlation between leucocyte count and short- and long-term outcomes. METHODS: Of our database of 1008 consecutive patients aged 15 to 49, we included those with leucocyte count measured within the first two days from stroke onset. Outcomes were three-month and long-term disability, death, and vascular events. Linear regression was used to explore baseline variables associated with leucocyte count. Logistic regression and Cox proportional models studied the association between leucocyte count and clinical outcomes. RESULTS: In our study cohort of 797 patients (61·7% males; mean age 41·4 years), mean leucocyte count was high: 8·8 ± 3·1 × 10(9) cells/L (Reference range: 3·4-8·2 × 10(9) cells/L). Higher leucocyte levels were associated with dyslipidaemia, smoking, peripheral arterial disease, stroke severity, and lesion size. After adjustment for age, gender, relevant risk factors, both continuous leucocyte count and the highest quartile of leucocyte count were independently associated with unfavourable three-month outcome. Regarding events in the long-term (follow-up 8·1 ± 4·2 years in survivors), no association between leucocyte count and the event risks appeared. CONCLUSIONS: Among young stroke patients, high leucocyte count was a common finding. It was associated with vascular disease and its risk factors as well as severity of stroke, but it was also independently associated with unfavourable three-month outcome in these patients. There was no association with the long-term outcome.
Terttu Heikinheimo; Jukka Putaala; Elena Haapaniemi; Markku Kaste; Turgut Tatlisumak
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  International journal of stroke : official journal of the International Stroke Society     Volume:  -     ISSN:  1747-4949     ISO Abbreviation:  Int J Stroke     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101274068     Medline TA:  Int J Stroke     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. International Journal of Stroke © 2013 World Stroke Organization.
Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
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