Document Detail

Leucine disposal and oxidation rates in the fetal lamb.
MedLine Citation:
PMID:  3796296     Owner:  NLM     Status:  MEDLINE    
To verify previous indirect evidence suggesting an important role of amino acids as substrates of fetal oxidative metabolism, leucine disposal and oxidation rates were measured in chronically catheterized fetal lambs during the last month of gestation. Under normal physiologic conditions the leucine oxidation rates were 6.43 +/- 1.02 mumol min-1 for fetuses with an average weight of 3.22 +/- 0.07 kg and comparable in magnitude to the fetal rate of leucine accretion. In seven animals studied before and during fasting, the fetal leucine oxidation rate increased with fasting from 5.8 +/- 1.0 to 10.8 +/- 1.3 mumol min-1. These data demonstrate that there is rapid oxidative degradation of leucine by the fetus and that the rate of this process increases in response to maternal fasting.
L C van Veen; C Teng; W W Hay; G Meschia; F C Battaglia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  36     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-02-13     Completed Date:  1987-02-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  48-53     Citation Subset:  IM    
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MeSH Terms
Fetal Blood / analysis
Fetus / metabolism*
Leucine / blood,  metabolism*
Maternal-Fetal Exchange
Placenta / metabolism
Sheep / embryology*
Grant Support
Reg. No./Substance:

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