Document Detail


Leucine disposal and oxidation rates in the fetal lamb.
MedLine Citation:
PMID:  3796296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To verify previous indirect evidence suggesting an important role of amino acids as substrates of fetal oxidative metabolism, leucine disposal and oxidation rates were measured in chronically catheterized fetal lambs during the last month of gestation. Under normal physiologic conditions the leucine oxidation rates were 6.43 +/- 1.02 mumol min-1 for fetuses with an average weight of 3.22 +/- 0.07 kg and comparable in magnitude to the fetal rate of leucine accretion. In seven animals studied before and during fasting, the fetal leucine oxidation rate increased with fasting from 5.8 +/- 1.0 to 10.8 +/- 1.3 mumol min-1. These data demonstrate that there is rapid oxidative degradation of leucine by the fetus and that the rate of this process increases in response to maternal fasting.
Authors:
L C van Veen; C Teng; W W Hay; G Meschia; F C Battaglia
Related Documents :
7100656 - Effects on the rate of increase in fetal girth of refeeding ewes after short periods of...
7405556 - Maternal and fetal metabolic responses to ritodrine in the sheep.
24738066 - Quantitative proteomics analysis of altered protein expression in the placental villous...
3378946 - Use of birth fluids and cervical stimulation in lamb fostering.
4037006 - Content of the collagen and elastin cross-links pyridinoline and the desmosines in the ...
16916256 - Noninvasive prenatal diagnosis by analysis of fetal dna in maternal plasma.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  36     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-02-13     Completed Date:  1987-02-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  48-53     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Fasting
Female
Fetal Blood / analysis
Fetus / metabolism*
Leucine / blood,  metabolism*
Maternal-Fetal Exchange
Oxidation-Reduction
Placenta / metabolism
Pregnancy
Sheep / embryology*
Grant Support
ID/Acronym/Agency:
HD-00781/HD/NICHD NIH HHS; HD-01866/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
61-90-5/Leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Brain uptake of ketones in rats with differing susceptibility to dietary obesity.
Next Document:  Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism i...