Document Detail

The Leu554Phe polymorphism in the E-selectin gene is associated with blood pressure in overweight people.
MedLine Citation:
PMID:  15076188     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Associations between circulating concentrations of E-selectin, blood pressure and obesity, and between the Leu554Phe (L/F554) polymorphism and blood pressure have been documented. OBJECTIVES: To investigate how the E-selectin L/F554 polymorphism is involved in longitudinal blood pressure changes, and how this polymorphism interacts with body mass index (BMI) on blood pressure. DESIGN AND PARTICIPANTS: For this study, 478 men and 546 women were selected from the Stanislas cohort, a French longitudinal study of volunteers for a free health check-up. These individuals underwent two examinations (t(0) and t(+5)) and were not taking medication that can affect blood pressure. RESULTS: At t(0), no relationship was observed between L/F554 polymorphism and blood pressure. However at t(+5), systolic blood pressure (SBP) was greater in individuals carrying the F allele, and the L/F554 polymorphism was associated with SBP in interaction with BMI (P < 0.001 in men and P < 0.05 for women). There was a steeper increase in SBP with BMI greater than 25 kg/m2 in carriers of the F allele than in LL homozygotes. Similar results were observed for diastolic blood pressure in men (P = 0.0103). CONCLUSION: These results suggest a BMI-specific effect of L/F554 polymorphism of the E-selectin gene on blood pressure, and strengthen the hypothesis that E-selectin is implicated in hypertension.
Jean-Brice Marteau; Catherine Sass; Michèle Pfister; Daniel Lambert; Mario Noyer-Weidner; Sophie Visvikis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  22     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-04-12     Completed Date:  2004-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  305-11     Citation Subset:  IM    
Unité INSERM U525 Equipe 4 Centre de Médecine Préventive, Nancy, France.
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MeSH Terms
Blood Pressure / genetics*
Body Mass Index
Cohort Studies
E-Selectin / genetics*
Longitudinal Studies
Middle Aged
Obesity / genetics,  physiopathology*
Polymorphism, Genetic*
Reg. No./Substance:
0/E-Selectin; 61-90-5/Leucine; 63-91-2/Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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