| The Leu554Phe polymorphism in the E-selectin gene is associated with blood pressure in overweight people. | |
| | |
MedLine Citation:
|
PMID: 15076188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Associations between circulating concentrations of E-selectin, blood pressure and obesity, and between the Leu554Phe (L/F554) polymorphism and blood pressure have been documented. OBJECTIVES: To investigate how the E-selectin L/F554 polymorphism is involved in longitudinal blood pressure changes, and how this polymorphism interacts with body mass index (BMI) on blood pressure. DESIGN AND PARTICIPANTS: For this study, 478 men and 546 women were selected from the Stanislas cohort, a French longitudinal study of volunteers for a free health check-up. These individuals underwent two examinations (t(0) and t(+5)) and were not taking medication that can affect blood pressure. RESULTS: At t(0), no relationship was observed between L/F554 polymorphism and blood pressure. However at t(+5), systolic blood pressure (SBP) was greater in individuals carrying the F allele, and the L/F554 polymorphism was associated with SBP in interaction with BMI (P < 0.001 in men and P < 0.05 for women). There was a steeper increase in SBP with BMI greater than 25 kg/m2 in carriers of the F allele than in LL homozygotes. Similar results were observed for diastolic blood pressure in men (P = 0.0103). CONCLUSION: These results suggest a BMI-specific effect of L/F554 polymorphism of the E-selectin gene on blood pressure, and strengthen the hypothesis that E-selectin is implicated in hypertension. |
| | |
Authors:
|
Jean-Brice Marteau; Catherine Sass; Michèle Pfister; Daniel Lambert; Mario Noyer-Weidner; Sophie Visvikis |
Related Documents
:
|
15583078 - Calcitonin gene-related peptide protects against hypertension-induced heart and kidney ... 19779468 - A single-nucleotide polymorphism in the gene encoding osteoprotegerin is associated wit... 8903618 - Renin-angiotensin system gene polymorphisms influence blood pressure and the response t... 8642188 - Angiotensin converting enzyme gene i/d polymorphism, blood pressure and the renin-angio... 22959488 - Association between methylmercury and cardiovascular risk factors in a native populatio... 16158308 - Deviations between transpalpebral tonometry using tgdc-01 and goldmann applanation tono... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of hypertension Volume: 22 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2004 Feb |
Date Detail:
|
Created Date: 2004-04-12 Completed Date: 2004-09-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 305-11 Citation Subset: IM |
Affiliation:
|
Unité INSERM U525 Equipe 4 Centre de Médecine Préventive, Nancy, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alleles Blood Pressure / genetics* Body Mass Index Cohort Studies Diastole E-Selectin / genetics* Female Heterozygote Homozygote Humans Leucine Longitudinal Studies Male Middle Aged Obesity / genetics, physiopathology* Phenylalanine Polymorphism, Genetic* Systole |
| Chemical | |
Reg. No./Substance:
|
0/E-Selectin; 61-90-5/Leucine; 63-91-2/Phenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic influences on blood pressure within the Stanislas Cohort.
Next Document: Smoking-dependent effects of the angiotensin-converting enzyme gene insertion/deletion polymorphism ...