| Letter: Psoriasis and Down syndrome: A report of three cases and a potential pathophysiologic link. | |
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MedLine Citation:
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PMID: 22747937 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Psoriasis is thought to result from an influx of Th1 and Th17 cells driven by the production of cytokines such as interferon (IFN)-gamma, IL-2, and tumor necrosis factor (TNF)-alpha elicited by skin immunocytes. We report three cases of patients with chronic plaque psoriasis and concomitant Down syndrome. Although there is no direct link between Down syndrome and the Th17 pathway, there are data supporting a dysregulation of the IFN system in this patient population. The percentage of Th1 lineage cells (IFN-gamma producing CD4+ and CD8+ T cells) is substantially higher in patients with Down syndrome and serum levels of IFN-gamma in patients with Down syndrome are significantly elevated when compared to healthy controls. We propose that people with Down syndrome have a greater prevalence of psoriasis secondary to both high serum levels of and an enhanced sensitivity to IFN-gamma. |
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Authors:
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Shana Marmon; Aieska De Souza; Bruce E Strober |
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Publication Detail:
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Type: Letter Date: 2012-06-15 |
Journal Detail:
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Title: Dermatology online journal Volume: 18 ISSN: 1087-2108 ISO Abbreviation: Dermatol. Online J. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-07-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610776 Medline TA: Dermatol Online J Country: United States |
Other Details:
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Languages: eng Pagination: 13 Citation Subset: IM |
Affiliation:
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Department of Dermatology, New York University, New York. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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