Document Detail

Letter: Psoriasis and Down syndrome: A report of three cases and a potential pathophysiologic link.
MedLine Citation:
PMID:  22747937     Owner:  NLM     Status:  In-Data-Review    
Psoriasis is thought to result from an influx of Th1 and Th17 cells driven by the production of cytokines such as interferon (IFN)-gamma, IL-2, and tumor necrosis factor (TNF)-alpha elicited by skin immunocytes. We report three cases of patients with chronic plaque psoriasis and concomitant Down syndrome. Although there is no direct link between Down syndrome and the Th17 pathway, there are data supporting a dysregulation of the IFN system in this patient population. The percentage of Th1 lineage cells (IFN-gamma producing CD4+ and CD8+ T cells) is substantially higher in patients with Down syndrome and serum levels of IFN-gamma in patients with Down syndrome are significantly elevated when compared to healthy controls. We propose that people with Down syndrome have a greater prevalence of psoriasis secondary to both high serum levels of and an enhanced sensitivity to IFN-gamma.
Shana Marmon; Aieska De Souza; Bruce E Strober
Related Documents :
18765087 - Hypertension and hepatic steatosis.
17118477 - Prevalence of the metabolic syndrome among korean adults using the new international di...
18273497 - Nonalcoholic fatty liver disease and metabolic syndrome: a concise review.
22401347 - Necrotizing fasciitis caused by serratia marcescens: a fatal complication of nephrotic ...
7108627 - Scintigraphic demonstration of ventriculo atrial conduction in the ventricular pacemake...
25304117 - Expanding the phenotype of spondylospinal thoracic dysostosis (the turkel-chen-johnson ...
Publication Detail:
Type:  Letter     Date:  2012-06-15
Journal Detail:
Title:  Dermatology online journal     Volume:  18     ISSN:  1087-2108     ISO Abbreviation:  Dermatol. Online J.     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610776     Medline TA:  Dermatol Online J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13     Citation Subset:  IM    
Department of Dermatology, New York University, New York.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  [Atypical presentation of cutaneous sporotrichosis in an alcoholic patient].
Next Document:  Letter: A Stewart-Treves syndrome of the lower limb.