Document Detail


Letter: Iatrogenic lipomatosis: a rare manifestation of treatment with a peroxisome proliferator-activated receptor gamma agonist.
MedLine Citation:
PMID:  20409422     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipomas are common benign neoplasms of adipose tissue. Lipomatosis, the progressive appearance of multiple lipomas, is most often associated with specific congenital, familial, or idiopathic syndromes. In one reported case, the development of multiple lipomas occurred as a result of treatment with rosiglitazone, a peroxisome proliferator-activated receptor (PPAR) gamma agonist. We report a second case of lipomatosis occurring as a result of treatment with a PPAR gamma agonist. This case occurred in a 77-year-old woman who developed multiple lipomas two years after beginning treatment with pioglitazone, a PPAR gamma agonist. Histopathologic examination confirmed these lesions to be lipomas. Within four weeks of discontinuation of pioglitazone, regression of the lipomas began. We describe a case of PPAR agonist-induced lipoma formation, review relevant literature, and provide a molecular mechanism for this side effect.
Authors:
Alisa Femia; Peter A Klein
Publication Detail:
Type:  Case Reports; Letter     Date:  2010-04-15
Journal Detail:
Title:  Dermatology online journal     Volume:  16     ISSN:  1087-2108     ISO Abbreviation:  Dermatol. Online J.     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610776     Medline TA:  Dermatol Online J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / drug effects
Aged
Diabetes Mellitus, Type 2 / drug therapy*
Female
Humans
Hypoglycemic Agents / adverse effects*,  therapeutic use
Iatrogenic Disease
Lipoma / chemically induced*,  diagnosis,  pathology
Neoplasms, Multiple Primary / chemically induced*,  diagnosis,  pathology
PPAR gamma / agonists*
Skin Neoplasms / chemically induced*,  diagnosis,  pathology
Thiazolidinediones / adverse effects*,  therapeutic use
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 0/PPAR gamma; 0/Thiazolidinediones; 111025-46-8/pioglitazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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