| Letter: Iatrogenic lipomatosis: a rare manifestation of treatment with a peroxisome proliferator-activated receptor gamma agonist. | |
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MedLine Citation:
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PMID: 20409422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipomas are common benign neoplasms of adipose tissue. Lipomatosis, the progressive appearance of multiple lipomas, is most often associated with specific congenital, familial, or idiopathic syndromes. In one reported case, the development of multiple lipomas occurred as a result of treatment with rosiglitazone, a peroxisome proliferator-activated receptor (PPAR) gamma agonist. We report a second case of lipomatosis occurring as a result of treatment with a PPAR gamma agonist. This case occurred in a 77-year-old woman who developed multiple lipomas two years after beginning treatment with pioglitazone, a PPAR gamma agonist. Histopathologic examination confirmed these lesions to be lipomas. Within four weeks of discontinuation of pioglitazone, regression of the lipomas began. We describe a case of PPAR agonist-induced lipoma formation, review relevant literature, and provide a molecular mechanism for this side effect. |
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Authors:
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Alisa Femia; Peter A Klein |
Publication Detail:
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Type: Case Reports; Letter Date: 2010-04-15 |
Journal Detail:
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Title: Dermatology online journal Volume: 16 ISSN: 1087-2108 ISO Abbreviation: Dermatol. Online J. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610776 Medline TA: Dermatol Online J Country: United States |
Other Details:
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Languages: eng Pagination: 15 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects Aged Diabetes Mellitus, Type 2 / drug therapy* Female Humans Hypoglycemic Agents / adverse effects*, therapeutic use Iatrogenic Disease Lipoma / chemically induced*, diagnosis, pathology Neoplasms, Multiple Primary / chemically induced*, diagnosis, pathology PPAR gamma / agonists* Skin Neoplasms / chemically induced*, diagnosis, pathology Thiazolidinediones / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 0/PPAR gamma; 0/Thiazolidinediones; 111025-46-8/pioglitazone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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