| Letrozole versus laparoscopic ovarian diathermy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial. | |
| | |
MedLine Citation:
|
PMID: 20577748 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
PURPOSE: To compare the effect of letrozole with laparoscopic ovarian diathermy (LOD) for ovulation induction in clomiphene citrate (CC) resistant women with polycystic ovary syndrome (PCOS). METHODS: Two hundred and sixty anovulatory women with CC-resistant PCOS were selected in this randomized controlled trial. Group A (n = 128) received 2.5 mg letrozole daily for 5 days for up to six cycles. Group B (n = 132) underwent LOD with 6 months follow-up. Outcome measures were ovulation rate, midcycle endometrial thickness, pregnancy, miscarriage and live birth rates. RESULTS: Ovulation occurred in 335/512 cycles (65.4%) in letrozole group and 364/525 cycles (69.3%) in LOD group without significant difference between both groups. Resumption of regular menstruation was similar in both treatment groups. A significant increase in midcycle endometrial thickness was observed in letrozole group (8.8 ± 1.1 mm vs. 7.9 ± 1.2 mm) (P < 0.05). Pregnancy rate was similar in both groups (15.6 vs. 17.5%). There were no statistical significant differences as regards miscarriage and live birth rates between both groups. No multiple pregnancy or ovarian hyperstimulation occurred in either group. CONCLUSION: Letrozole and LOD are equally effective for inducing ovulation and achieving pregnancy in CC-resistant PCOS patients. |
| | |
Authors:
|
Hatem Abu Hashim; Abdel Maged Mashaly; Ahmed Badawy |
Related Documents
:
|
1986968 - Endometrial histology after first trimester spontaneous abortion. 9021378 - Endometrial pattern in diethylstilboestrol-exposed women undergoing in-vitro fertilizat... 12078838 - The use of gnrh antagonists in ovarian stimulation. 17314078 - The effectiveness of a fertility awareness based method to avoid pregnancy in relation ... 367428 - The effect of cervical encerclage on plasma prostaglandin concentrations during early h... 10519658 - Ciguatoxin reduces larval survivability in finfish. |
Publication Detail:
|
Type: Journal Article Date: 2010-06-26 |
Journal Detail:
|
Title: Archives of gynecology and obstetrics Volume: 282 ISSN: 1432-0711 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
|
Languages: eng Pagination: 567-71 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt. hatem_ah@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [Problems associated with treating ocular disease in underlying inflammatory rheumatic disease].
Next Document: Does intercourse during menses increase the risk for sexually transmitted disease?