Document Detail


Lethal toxin of Clostridium sordellii is associated with fatal equine atypical myopathy.
MedLine Citation:
PMID:  20189733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lethal toxin of Clostridium sordellii (TcsL) evokes severe, mostly fatal disease patterns like toxic shock syndrome in humans and animals. Since this large clostridial toxin-induced severe muscle damaging when injected intramuscularly into mice, we hypothesized that TcsL is also associated with equine atypical myopathy (EAM), a fatal myodystrophy of hitherto unknown etiology. Transmission electron microscopy revealed skeletal and heart muscles of EAM-affected horses to undergo degeneration ultrastructurally similar to the damage found in TcsL-treated mice. Performing immunohistochemistry, myofibers of EAM-affected horses specifically reacted with sera derived from horses with EAM as well as an antibody specific for the N-terminal part of TcsL, while both antibodies failed to bind to the myofibers of either healthy horses or those with other myopathies. The presence of TcsL in myofibers of horses with EAM suggests that it plays a role as trigger or even as lethal factor in this disease.
Authors:
Lucia Unger-Torroledo; Reto Straub; Andrea D Lehmann; Franziska Graber; Christina Stahl; Joachim Frey; Vinzenz Gerber; Hans Hoppeler; Oliver Baum
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Publication Detail:
Type:  Journal Article     Date:  2010-02-01
Journal Detail:
Title:  Veterinary microbiology     Volume:  144     ISSN:  1873-2542     ISO Abbreviation:  Vet. Microbiol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705469     Medline TA:  Vet Microbiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  487-92     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Equine Clinic, Department of Veterinary Clinical Studies, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Toxins / isolation & purification*,  metabolism
Clostridium Infections / microbiology,  veterinary*
Clostridium sordellii / metabolism*
Female
Horse Diseases / microbiology*
Horses
Male
Muscle, Skeletal / pathology,  ultrastructure
Muscular Diseases / microbiology*
Myocardium / ultrastructure
Chemical
Reg. No./Substance:
0/Bacterial Toxins; 0/lethal toxin LT, Clostridium sordellii

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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