Document Detail


Lethal of scute requires overexpression of daughterless to elicit ectopic neuronal development during embryogenesis in Drosophila.
MedLine Citation:
PMID:  9178258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Classical genetics indicates that the achaete-scute gene complex (AS-C) of Drosophila promotes development of neural progenitor cells. To further analyze the function of proneural genes, we have studied the effects of Gal4-mediated expression of lethal of scute, a member of the AS-C, during embryogenesis. Expression of lethal of scute forces progenitor cells of larval internal sensory organs, which are normally committed to this fate independently of the activity of the AS-C, to take on features of external sensory organs. Supernumerary neural cells can be induced ectopically only if daughterless is overexpressed, either alone or together with lethal of scute: cells of the amnioserosa and the hindgut then express neuronal markers. Furthermore, cells of the proctodeal anlage, which normally lack neural competence, acquire the ability to develop as neuroblasts following transplantation into the neuroectoderm. We show here that activated Notch prevents the cells of the neuroectoderm from forming extra neural tissue when they express an excess of proneural proteins. Under the present conditions, lateral inhibition is thus dominant over the activity of proneural genes.
Authors:
B Giebel; I Stüttem; U Hinz; J A Campos-Ortega
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mechanisms of development     Volume:  63     ISSN:  0925-4773     ISO Abbreviation:  Mech. Dev.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-29     Completed Date:  1997-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9101218     Medline TA:  Mech Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  75-87     Citation Subset:  IM    
Affiliation:
Institut für Entwicklungsbiologie, Universität zu Köln, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Basic Helix-Loop-Helix Transcription Factors
Biological Markers
Chromosome Mapping
DNA-Binding Proteins / biosynthesis*
Drosophila Proteins*
Drosophila melanogaster / embryology*,  genetics
Embryonic Induction
Fungal Proteins / biosynthesis
Gene Expression Regulation, Developmental*
Genes, Insect
Helix-Loop-Helix Motifs
Insect Hormones / biosynthesis
Nervous System / embryology
Neurons / physiology*
Nuclear Proteins / biosynthesis*
Recombinant Fusion Proteins / biosynthesis
Saccharomyces cerevisiae Proteins*
Transcription Factors / biosynthesis*
Chemical
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/Biological Markers; 0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Fungal Proteins; 0/GAL4 protein, S cerevisiae; 0/Insect Hormones; 0/Nuclear Proteins; 0/Recombinant Fusion Proteins; 0/Saccharomyces cerevisiae Proteins; 0/Transcription Factors; 0/daughterless protein, Drosophila; 0/lethal of scute protein, Drosophila

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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