| Lethal poisoning with ethiofencarb and ethanol. | |
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MedLine Citation:
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PMID: 19796510 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ethiofencarb is one of the carbamate compounds, which are, in general, less toxic than organophosphorus insecticides. This is due to their reversible acetylcholinesterase inhibition and relative inability to cross the blood-brain barrier. Generally, ethiofencarb is regarded to be of low toxicity (LD(50) > 200 mg/kg); however, severe poisoning and death are not uncommon. To our knowledge, no measurements of ethiofencarb and its metabolites in human postmortem whole blood have been published. We present here a case report of fatal ethiofencarb intoxication with quantitative analysis of ethiofencarb and its metabolites in ante- and postmortem blood. In addition, postmortem urine was collected and analyzed. A 56-year-old man, who worked as a gardener, was found in poor condition, sitting in his car seat. He had been vomiting. The man was admitted to the local hospital about 1 h later. At admission, he was conscious, but unable to speak clearly. His condition deteriorated, and he developed severe pulmonary edema. Resuscitation with atropine and adrenaline were attempted, but he died approximately 3 h after admission. The analysis of postmortem peripheral blood revealed 0.12 g/100 mL ethanol, 26.4 mg/L ethiofencarb, 37.9 mg/L ethiofencarbsulfoxide, and 0.9 mg/L ethiofencarbsulfone. Ethanol (0.26 g/100 mL), ethiofencarb, ethiofencarbsulfoxide, and ethiofencarbsulfone were also detected in urine. |
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Authors:
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Muhammad S J Al-Samarraie; Ritva Karinen; Torleiv Rognum; Inger Hasvold; Mimi Opdal Stokke; Asbjørg S Christophersen |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of analytical toxicology Volume: 33 ISSN: 0146-4760 ISO Abbreviation: J Anal Toxicol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-02 Completed Date: 2009-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 389-92 Citation Subset: IM |
Affiliation:
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Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Oslo, Norway. Muhammad.Al-Samarraie@fhi.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autopsy Biotransformation Calibration Carbamates / blood, poisoning*, urine Central Nervous System Depressants / poisoning* Chromatography, High Pressure Liquid Ethanol / poisoning* Fatal Outcome Humans Insecticides / blood, poisoning*, urine Male Middle Aged Pulmonary Edema / chemically induced Reference Standards Spectrometry, Mass, Electrospray Ionization |
| Chemical | |
Reg. No./Substance:
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0/Carbamates; 0/Central Nervous System Depressants; 0/Insecticides; 29973-13-5/croneton; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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