Document Detail


Lethal maternal sepsis caused by Campylobacter jejuni: pathogen preserved in placenta and identified by molecular methods.
MedLine Citation:
PMID:  9436972     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Campylobacter jejuni is one of the most common organisms in the etiology of febrile diarrhea. Bacteremia is reported to be rare. In pregnant women, however, C. jejuni (previous name, Vibrio fetus) can cause fetal death. We report the case of a pregnant woman with enterocolitis and sepsis that caused the death of the fetus and, 11 days later, the death of the mother. C. jejuni was detected by culture techniques at the time of the first symptoms but not during the subsequent course of disease. Bacteria were detected by silver staining and electron microscopic examination in the placenta, but for identification, we used molecular methods. From formalin-fixed, paraffin-embedded placental tissues, a part of the bacterial 16S rRNA was amplified by broad-range polymerase chain reaction, which resulted in a 461-nucleotide sequence. Direct sequencing and comparison to reference sequences revealed C. jejuni as the causative agent for the sepsis and deaths. With this approach, the adverse outcome could be related etiologically to the same infectious agent identified at the onset of the disease. From this and other recent reports, we conclude that C. jejuni must be considered an important pathogen in pregnancy.
Authors:
A Meyer; T Stallmach; D Goldenberger; M Altwegg
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  10     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-02-11     Completed Date:  1998-02-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1253-6     Citation Subset:  IM    
Affiliation:
Department of Pathology, University Hospital Zürich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
Campylobacter jejuni / isolation & purification*
Colitis / pathology
DNA, Bacterial / analysis
Fatal Outcome
Female
Fetal Diseases / microbiology
Humans
Infectious Disease Transmission, Vertical
Male
Placenta / microbiology*,  ultrastructure
Pregnancy
Pregnancy Complications, Infectious / pathology*
Sepsis / diagnosis,  genetics,  transmission*
Chemical
Reg. No./Substance:
0/DNA, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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