| Lethal effects of a linoleic acid hydroperoxide and its autoxidation products, unsaturated aliphatic aldehydes, on human diploid fibroblasts. | |
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MedLine Citation:
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PMID: 3664790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lethal effects of linoleic acid and its hydroperoxide on human diploid fibroblasts were quite similar, and that of the reaction mixture from the autoxidation of the hydroperoxide was considerable. Some unsaturated aliphatic aldehydes, the secondary products of the hydroperoxide autoxidation, were identified and their toxicity toward the cells was examined. Among them, (E,E)-2,4-nonadienal, (E,E)-2,4-decadienal, and (E)-4-hydroxy-2-nonenal were the most toxic; e.g., in the presence of 25 microM nonadienal, decadienal, or hydroxynonenal, 75, 90, or almost 100% of the cells, respectively, underwent lysis within one day. Generally, alkenals were toxic and alkanals non-toxic. The toxicity was enhanced as the number of double bonds in each molecule was increased and also as the carbon chain was lengthened. |
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Authors:
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T Kaneko; S Honda; S Nakano; M Matsuo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemico-biological interactions Volume: 63 ISSN: 0009-2797 ISO Abbreviation: Chem. Biol. Interact. Publication Date: 1987 |
Date Detail:
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Created Date: 1987-11-25 Completed Date: 1987-11-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0227276 Medline TA: Chem Biol Interact Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 127-37 Citation Subset: IM |
Affiliation:
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Tokyo Metropolitan Institute of Gerontology, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes
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toxicity* Cells, Cultured Fibroblasts / drug effects* Humans Linoleic Acid Linoleic Acids / toxicity* Lipid Peroxides / toxicity* Oxidation-Reduction |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Linoleic Acids; 0/Lipid Peroxides; 2197-37-7/Linoleic Acid; 25657-09-4/linoleic acid hydroperoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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