| Lethal effects of Clostridium perfringens epsilon toxin are potentiated by alpha and perfringolysin-O toxins in a mouse model. | |
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MedLine Citation:
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PMID: 17997054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epsilon toxin (ETX) is the most important virulence factor of Clostridium perfringens type D. Two other important toxins, alpha toxin (CPA) and perfringolysin-O (PFO), are encoded and potentially produced by most C. perfringens type D isolates. The biological effects of these toxins are dissimilar although they are all lethal. Since the possible interaction of these toxins during infection is unknown, the effects of CPA and PFO on the lethal activity of ETX were studied in a mouse model. Mice were injected intravenously or intragastrically with CPA or PFO with or without ETX. Sublethal doses of CPA or PFO did not affect the lethality of ETX when either was injected together with the latter intravenously. However, sublethal or lethal doses of CPA or PFO resulted in reduction of the survival time of mice injected simultaneously with ETX when compared with the intravenous effect of ETX injected alone. When PFO was inoculated intragastrically with ETX, a reduction of the survival time was observed. CPA did not alter the survival time when inoculated intragastrically with ETX. The results of the present study suggest that both CPA and PFO have the potential to enhance the ETX lethal effects during enterotoxemia in natural hosts such as sheep and goats. |
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Authors:
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Mariano E Fernandez-Miyakawa; B Helen Jost; Stephen J Billington; Francisco A Uzal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-02 |
Journal Detail:
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Title: Veterinary microbiology Volume: 127 ISSN: 0378-1135 ISO Abbreviation: Vet. Microbiol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-04 Completed Date: 2008-05-15 Revised Date: 2011-02-07 |
Medline Journal Info:
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Nlm Unique ID: 7705469 Medline TA: Vet Microbiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 379-85 Citation Subset: IM |
Affiliation:
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California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, 105 W Central Avenue, San Bernardino, CA 92408, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Toxins / biosynthesis, toxicity* Calcium-Binding Proteins / biosynthesis, toxicity* Clostridium perfringens / metabolism, pathogenicity* Drug Synergism Female Hemolysin Proteins / biosynthesis, toxicity* Injections, Intravenous Lethal Dose 50 Male Mice Mice, Inbred BALB C Time Factors Type C Phospholipases / biosynthesis, toxicity* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI056177-04/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Toxins; 0/Calcium-Binding Proteins; 0/Clostridium perfringens epsilon-toxin; 0/Hemolysin Proteins; 71329-60-7/Clostridium perfringens theta-toxin; EC 3.1.4.-/Type C Phospholipases; EC 3.1.4.3/alpha toxin, Clostridium perfringens |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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