Document Detail


Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction.
MedLine Citation:
PMID:  17485403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatalities due to anthrax are associated with severe hypotension suggesting that the toxins generated from Bacillus anthracis, lethal toxin (LeTx) and edema toxin (EdTx), have cardiovascular effects. Here, we demonstrate the effects of these toxins and characterize their effects by echocardiography. LeTx leads to a significant reduction in ejection fraction, decreased velocity of propagation (diastolic dysfunction), decreased velocity of circumferential fiber shortening (decreased contractility), and increased LV systolic area (pathophysiology). EdTx leads to a significant reduction in left ventricular volumes and cardiac output (reduced stroke volume) but does not cause significant change in ejection fraction or contractility. These results indicate that LeTx reduces left ventricular systolic function and EdTx reduces preload but does not have direct myocardial effects. Together, these findings suggest that LeTx and EdTx exert distinct hemodynamic dysfunction associated with anthrax infection.
Authors:
Linley E Watson; Jonathan Mock; Hind Lal; Guangrong Lu; Raymond W Bourdeau; Wei-Jen Tang; Stephen H Leppla; David E Dostal; Arthur E Frankel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-05-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  12     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-08     Completed Date:  2007-06-29     Revised Date:  2009-09-04    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4670-5     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Scott and White Memorial Hospital, Scott, Sherwood and Brindley Foundation and Cardiovascular Research Institute, Texas A & M University System, Health Science Center College of Medicine, Temple, TX 76502, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenylate Cyclase / pharmacology*
Animals
Antigens, Bacterial / pharmacology*
Bacterial Toxins / pharmacology*
Electrocardiography
Heart / drug effects*,  physiology
Humans
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
R01 CA76178/CA/NCI NIH HHS; R01 CA90263/CA/NCI NIH HHS; R01 HL68838/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Bacterial Toxins; 0/anthrax toxin; EC 4.6.1.1/Adenylate Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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