Document Detail

Lethal candida sepsis associated with myeloperoxidase deficiency and pre-eclampsia.
MedLine Citation:
PMID:  17614858     Owner:  NLM     Status:  MEDLINE    
We report on a 27-year-old primipara suffering from pre-eclampsia who died within 2 days postpartum. Toxemia with disseminated intravascular coagulation (DIC) and acute renal failure had masked the symptoms of invasive candida esophagitis and disseminated candidiasis in both lungs. Candida sepsis was discovered as the cause of death at postmortem examination. Myeloperoxidase (MPO) deficiency was identified as having supported the invasive candida infection. We conclude that a combination of MPO-deficiency and gestational toxemia may indicate increased susceptibility to severe candida infections.
Thomas Kalinski; Kathleen Jentsch-Ullrich; Sara Fill; Brigitte König; Serban-Dan Costa; Albert Roessner
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  115     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-09-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  875-80     Citation Subset:  IM    
Department of Pathology, Otto-von-Guericke-University, Magdeburg, Germany.
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MeSH Terms
Candida albicans / isolation & purification*
Candidiasis / complications,  diagnosis*
Esophagitis / diagnosis*,  microbiology,  pathology
Fatal Outcome
Neutrophils / enzymology
Peroxidase / analysis,  deficiency*
Sepsis / diagnosis*,  microbiology
Reg. No./Substance:

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