Document Detail


Lethal Effect of a Single Dose of Rasburicase in a Preterm Newborn Infant.
MedLine Citation:
PMID:  23209099     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This case report describes a preterm newborn infant who was treated with a single dose of rasburicase for an increase in uric acid level. He died on the third day as a result of complications of hemolysis, which appeared to be precipitated by rasburicase. The patient's death was preceded by progressive respiratory insufficiency, lactic acidosis, and hyperbilirubinemia, culminating in refractory hypoxia and hypotension. A postmortem assay for glucose-6-phosphate dehydrogenase showed deficiency and the glucose-6-phosphate dehydrogenase Mediterranean genotype.
Authors:
Patrizia Zaramella; Alessandra De Salvia; Martina Zaninotto; Maura Baraldi; Giovanni Capovilla; Domenico De Leo; Lino Chiandetti
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  Pediatrics     Volume:  -     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
NICU, Women's and Children's Health Department, and.
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