Document Detail

Lethal Clostridium difficile Colitis Associated with Paclitaxel and Carboplatin Chemotherapy in Ovarian Carcinoma: Case Report and Review of the Literature.
MedLine Citation:
PMID:  20706661     Owner:  NLM     Status:  In-Data-Review    
Clostridium difficile colitis, although rare, could represent a serious complication following chemotherapy. Prior antibiotic use has been considered the single most important risk factor in the development of C. difficile infection. Recently, the association between antineoplastic therapy and C. difficile-associated diarrhea in the absence of a prior antibiotic therapy has become more apparent. A 75-year-old woman with serous adenocarcinoma of the ovary developed lethal pancolitis caused by C. difficile after five cycles of paclitaxel- and carboplatin-based chemotherapy. She presented with diarrhea, coffee-ground emesis, and oliguria and was hospitalized immediately for aggressive treatment. Despite all the medical efforts, her condition worsened and she died after twenty days. We describe the second case reported of a patient developing a severe C. difficile colitis following chemotherapy without any recent antibiotic use and review the data of the literature, emphasizing the need to a prompt diagnosis and management that can significantly decrease the morbidity and life-threatening complications associated with this infection.
V Masciullo; S Mainenti; D Lorusso; P A Margariti; G Scambia
Publication Detail:
Type:  Journal Article     Date:  2010-07-18
Journal Detail:
Title:  Obstetrics and gynecology international     Volume:  2010     ISSN:  1687-9597     ISO Abbreviation:  Obstet Gynecol Int     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517078     Medline TA:  Obstet Gynecol Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  -    
Division of Gynecologic Oncology, Catholic University of Sacred Heart, L. go A. Gemelli, 8, 00168 Rome, Italy.
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