| Lessons learned from variation in response to therapy in clinical trials. | |
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MedLine Citation:
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PMID: 20074785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the past, we viewed lack of response to asthma medications as a rare event. Based on recent studies, we now expect significant variation in treatment response for all asthma medications. However, little information is available about methods to predict favorable treatment response. Research conducted in the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education Network verified this variability in response to several long-term control medications, specifically inhaled corticosteroids and leukotriene receptor antagonists, in adults and children with mild-to-moderate persistent asthma. The networks also identified potential methods to use patients' characteristics, such as age and allergic status, and biomarkers, such as bronchodilator response, exhaled nitric oxide, and urinary leukotrienes, to help predict response to inhaled corticosteroids and leukotriene receptor antagonists and to determine which of the 2 treatments might be more effective in individual patients. This information now assists the clinician in personalizing asthma treatment at the time of initiating long-term control therapy. |
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Authors:
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Stanley J Szefler; Richard J Martin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-01-13 |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 125 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-04-06 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 285-92; quiz 293-4 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA. szeflers@njhealth.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Asthmatic Agents
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therapeutic use* Asthma / drug therapy* Clinical Trials as Topic* Humans Treatment Outcome* |
| Grant Support | |
ID/Acronym/Agency:
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1 UL1 RR025780/RR/NCRR NIH HHS; AI-25496/AI/NIAID NIH HHS; HL 51834/HL/NHLBI NIH HHS; HL075416/HL/NHLBI NIH HHS; HL081335/HL/NHLBI NIH HHS; HL087811/HL/NHLBI NIH HHS; HL64288/HL/NHLBI NIH HHS; HR-16048/HR/NHLBI NIH HHS; R21 HL087811-02/HL/NHLBI NIH HHS; U01 HL075416-07/HL/NHLBI NIH HHS; U10 HL064288-10/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Asthmatic Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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