Document Detail


Lessons in hypertension from new clinical trials.
MedLine Citation:
PMID:  19940415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three important principles have emerged from recent epidemiologic and clinical studies in hypertension. First, patients with hypertension most often have other cardiovascular risk factors such as obesity and diabetes. Second, hypertension remains grossly undertreated. Third, at blood pressure levels once considered "high-normal," early organ damage may already be taking place in patients with multiple risk factors that, without treatment, can eventually lead to cardiovascular morbidity and mortality. The concept of evaluating global or overall risk is gaining wide acceptance, and US treatment guidelines may soon reflect these findings and assist clinicians in identifying individuals who are most likely to benefit from therapy. Results from clinical trials suggest that among the various pharmacologic agents available to treat hypertension, blockers of the renin-angiotensin system are effective in type 2 diabetes and chronic kidney disease, conditions that often occur in conjunction with hypertension.
Authors:
Shawna D Nesbitt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Postgraduate medicine     Volume:  121     ISSN:  1941-9260     ISO Abbreviation:  Postgrad Med     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-26     Completed Date:  2010-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401147     Medline TA:  Postgrad Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-43     Citation Subset:  AIM; IM    
Affiliation:
University of Texas Southwestern Medical Center, Dallas, TX 75390-8586, USA. shawna.nesbitt@utsouthwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II Type 1 Receptor Blockers / pharmacology,  therapeutic use*
Antihypertensive Agents / pharmacology,  therapeutic use*
Cardiovascular Diseases / epidemiology,  prevention & control
Drug Therapy, Combination
Humans
Hypertension / drug therapy*,  epidemiology,  prevention & control*
Metabolic Syndrome X / epidemiology,  therapy
Practice Guidelines as Topic
Reference Values
World Health
Chemical
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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