| Lessons from single cell organisms: insights into the antimicrobial and toxic effects of peritoneal dialysate bases. | |
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MedLine Citation:
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PMID: 20438533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although it was first described over a quarter of a century ago, the mechanisms behind the antimicrobial activity of fresh peritoneal dialysate have been poorly understood. Recent insight into the biochemistry appears to suggest that at least part of the effect resides in the salts of the carboxylic acids. An understanding of the metabolic pathways of both sensitive and resistant organisms has not only led to an understanding of the mechanisms of the antimicrobial effect, but also may have provided the insight for future studies to reduce toxicity to the peritoneal membrane. While our knowledge base in this area is still evolving, an improved understanding of the biochemical basis of both the antibacterial effect and toxicity of the salts of carboxylic acids in peritoneal dialysate can only prove useful. |
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Authors:
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Charles J Diskin |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 14 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-04 Completed Date: 2010-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
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Languages: eng Pagination: 127-35 Citation Subset: IM |
Affiliation:
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Department of Hypertension, Nephrology, Dialysis and Transplantation, Auburn University, Opelika, AL 36801, USA. hndt512@bellsouth.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteria / metabolism Carboxylic Acids / chemistry, metabolism* Dialysis Solutions / chemistry, metabolism* Humans Peritoneal Dialysis / methods* Peritoneum / chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Carboxylic Acids; 0/Dialysis Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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