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Lessons from the heart and ischemic limbs: midkine as anti-inflammatory mediator for kidney diseases?
MedLine Citation:
PMID:  23208536     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Inflammatory responses ensuing ischemia involve the release of numerous mediators. Among these the heparin-binding growth factor midkine has been recognized as a potent inducer of neoangiogenesis. In a recent publication, the release of midkine has been studied in different in vitro models, and effects of abrogated midkine expression by means of genetic knockout has been analyzed in ischemia models of the limbs. The observed effects indicate a profound effect exerted by midkine under ischemia in the coordination of the inflammatory response and neoangiogenesis.
Authors:
Delia Lidia Salaru; Peter R Mertens
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  International urology and nephrology     Volume:  -     ISSN:  1573-2584     ISO Abbreviation:  Int Urol Nephrol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke-University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.
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