Document Detail


Lessons from congenital neutropenia: 50 years of progress in understanding myelopoiesis.
MedLine Citation:
PMID:  18544696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Severe congenital neutropenia (SCN) was first described just over 50 years ago. The progress in elucidating the clinical features and molecular pathophysiology of SCN closely parallels the progressive growth in our understanding of myelopoiesis. In this historical review, I have delineated this parallel progression in our understanding of the processes of granulocyte differentiation and the pathogenesis of congenital neutropenia. SCN is a heterogeneous disease that can serve as a model for the failure of myelopoiesis, and dissection of its pathogenesis has yielded important insights into the normal process of myeloid development.
Authors:
Nancy Berliner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood     Volume:  111     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-11     Completed Date:  2008-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5427-32     Citation Subset:  AIM; IM    
Affiliation:
Division of Hematology, Brigham and Women's Hospital, Boston, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Humans
Myelopoiesis / physiology*
Neutropenia / congenital,  genetics*,  physiopathology*

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