| Lessons from clinical trials in African Burkitt lymphoma. | |
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MedLine Citation:
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PMID: 19620863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The center of gravity of the AIDS epidemic has moved - in 2007, 67% of all persons living with HIV infection and 72% of all deaths from AIDS occurred in Africa. The present review focuses on the treatment of an AIDS-defining malignancy, Burkitt lymphoma, since the discovery of the tumor in 1958 to provide a backdrop to the increasing necessity of dealing with AIDS-associated Burkitt lymphoma in Africa. RECENT FINDINGS: In Africa, it appears that AIDS-associated Burkitt lymphoma is increasing, but although treatment outcome is presently poor, the demonstration that highly active antiretroviral therapy permits the same treatment results to those in AIDS-unassociated Burkitt lymphoma provides hope for the future. SUMMARY: In the 1960s, the extraordinary response of Burkitt lymphoma to chemotherapy provided considerable encouragement to pioneer oncologists. Within little more than a decade, the most active drugs, the value of combination chemotherapy, and the need for intrathecal treatment, as well as the risk of tumor lysis syndrome had been demonstrated, providing a platform on which further advances could be made in resource-rich countries. Since that time, little progress has been made in Africa, but recent collaborative projects have shown that improved treatment outcome can be achieved at low cost. The impact of the HIV epidemic on the epidemiology and treatment of African Burkitt lymphoma will receive increasing focus in the coming years. |
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Authors:
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Ian Magrath |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in oncology Volume: 21 ISSN: 1531-703X ISO Abbreviation: Curr Opin Oncol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-05 Completed Date: 2010-01-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007265 Medline TA: Curr Opin Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 462-8 Citation Subset: IM |
Affiliation:
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International Network for Cancer Treatment and Research, Brussels, Belgium. imagrath@inctr.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications* Africa / epidemiology Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Antiretroviral Therapy, Highly Active Burkitt Lymphoma / complications, drug therapy*, epidemiology Clinical Trials as Topic Combined Modality Therapy Humans Incidence Lymphoma, AIDS-Related / drug therapy*, radiotherapy, surgery |
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