Document Detail


Lessons from a canine model of compensatory lung growth.
MedLine Citation:
PMID:  15563942     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For over a century, canines have been used to study adaptation to surgical lung resection or pneumonectomy (PNX) that results in a quantifiable and reproducible loss of lung units. As reviewed by Schilling (1965), the first successful experimental pneumonectomies were performed in dogs and rabbits in 1881. By the early 1920s, it was appreciated that dogs can function normally with one remaining lung that increases in volume to fill the thoracic cavity (Andrus, 1923; Heuer and Andrus, 1922; Heuer and Dunn, 1920); these pioneering observations paved the way for surgeons to perform major lung resection in patients. Reports in the 1950s (Schilling et al., 1956) detail surprisingly well-preserved work performance in dogs following staged resection of up to 70% of lung mass. Since then, the bulk of the literature on post-PNX adaptation has shifted to rodents, especially for defining molecular mediators of compensatory lung growth. Because rodents are smaller and easier to handle, more animals can be studied over a shorter duration, resulting in time and cost savings. On the other hand, key aspects of lung anatomy, development, and time course of response in the rodent do not mimic those in the human subject, and few rodent studies have related structural adaptation to functional consequences. In larger mammals, anatomical lung development more closely resembles that in humans, and physiological function can be readily measured. Because dogs are natural athletes, functional limits of compensation can be characterized relatively easily by stressing oxygen transport at peak exercise. Thus, the canine model remains useful for relating structure to function, defining sources and limits of adaptation as well as evaluating therapeutic manipulation. This chapter summarizes key concepts of compensatory lung growth that have been consolidated from canine studies: (i) structure-function relationships during adaptation, (ii) dysanaptic (unequal) nature of compensation, and (iii) signals for initiation of cellular growth.
Authors:
Connie C W Hsia
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current topics in developmental biology     Volume:  64     ISSN:  0070-2153     ISO Abbreviation:  Curr. Top. Dev. Biol.     Publication Date:  2004  
Date Detail:
Created Date:  2004-11-26     Completed Date:  2005-02-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0163114     Medline TA:  Curr Top Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-32     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Capillaries / anatomy & histology,  metabolism
Dogs*
Epiphyses / growth & development
Humans
Lung / anatomy & histology,  blood supply,  growth & development*,  physiology
Models, Animal
Neovascularization, Physiologic
Pneumonectomy
Pulmonary Alveoli / blood supply,  growth & development
Grant Support
ID/Acronym/Agency:
HL-45716/HL/NHLBI NIH HHS; HL-54060/HL/NHLBI NIH HHS; HL62873/HL/NHLBI NIH HHS; R01 HL-40070/HL/NHLBI NIH HHS

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