Document Detail


Lessons from animal studies for the treatment of invasive human infections due to uncommon fungi.
MedLine Citation:
PMID:  21493649     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Clinical experience in the management of opportunistic infections, especially those caused by less common fungi, is, due to their rarity, very scarce; therefore, the most effective treatments remain unknown. The ever-increasing numbers of fungal infections due to opportunistic fungi have repeatedly proven the limitations of the antifungal armamentarium. Moreover, some of these fungi, such as Fusarium spp. or Scedosporium spp., are innately resistant to almost all the available antifungal drugs, which makes the development of new and effective therapies a high priority. Since it is difficult to conduct randomized clinical trials in these uncommon mycoses, the use of animal models is a good alternative for evaluating new therapies. This is an extensive review of the numerous studies that have used animal models for this purpose against a significant number of less common fungi. A table describing the different studies performed on the efficacy of the different drugs tested is included for each fungal species. In addition, there is a summary table showing the conclusions that can be derived from the analysis of the studies and listing the drugs that showed the best results. Considering the wide variability in the response to the antifungals that the different strains of a given species can show, the table highlights the drugs that showed positive results using at least two parameters for evaluating efficacy against at least two different strains without showing any negative results. These data can be very useful for guiding the treatment of rare infections when there is very little experience or when controversial results exist, or when treatment fails.
Authors:
Josep Guarro
Related Documents :
10541419 - Chlamydia pneumoniae, asthma, and copd: what is the evidence?
24167679 - Clozapine treatment of patients with refractory schizophrenia, concurrent dengue infect...
21382129 - Pleural infection: changing bacteriology and its implications.
22679519 - Genetics of host response to leishmania tropica in mice - different control of skin pat...
22876869 - A mathematical model for the dynamics of malaria in mosquitoes feeding on a heterogeneo...
24263169 - Nebulized voriconazole in infections with scedosporium apiospermum - case report and re...
21414189 - Innate immune response in experimentally induced bovine intramammary infection with sta...
16784449 - Identification of candida fabianii as a cause of lethal septicaemia.
11305389 - Pemphigus vulgaris and disseminated nocardiosis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-14
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  -     ISSN:  1460-2091     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Mycology Unit, Medical School, IISPV, Rovira i Virgili University, 43201 Reus, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacokinetics of the HIV integrase inhibitor S/GSK1349572 co-administered with acid-reducing agen...
Next Document:  An optimal peak alignment for comprehensive two-dimensional gas chromatography mass spectrometry usi...