| Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing. | |
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MedLine Citation:
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PMID: 14644139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nod2 (Card15) belongs to the family of the recently described Nod molecules, which also includes the closely related protein Nod1 (Card4). Nod proteins have been initially described as intracellular activators of the caspase and NF-kappaB signaling pathways. Recent progress has enabled research to demonstrate genetically that NOD2 (CARD15) is involved in the predisposition to Crohn's disease and Blau syndrome. In addition, biochemical evidence has unraveled the role of Nod1 (Card4) and Nod2 (Card15) as intracellular sensors of bacterial peptidoglycan. Together, studies on Nod2 (Card15) provide a conceptual link between inflammatory disorders, such as Crohn's disease and Blau syndrome, and bacterial sensing. |
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Authors:
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Stephen E Girardin; Jean Pierre Hugot; Philippe J Sansonetti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in immunology Volume: 24 ISSN: 1471-4906 ISO Abbreviation: Trends Immunol. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-02-06 Revised Date: 2008-05-13 |
Medline Journal Info:
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Nlm Unique ID: 100966032 Medline TA: Trends Immunol Country: England |
Other Details:
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Languages: eng Pagination: 652-8 Citation Subset: IM |
Affiliation:
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Unité de Pathogénie Microbienne Moléculaire, INSERM U389, Paris, France. girardin@pasteur.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Infections / immunology Carrier Proteins / chemistry, physiology* Crohn Disease / immunology*, microbiology Genetic Predisposition to Disease Humans Intracellular Signaling Peptides and Proteins* Nod2 Signaling Adaptor Protein Peptidoglycan / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/NOD2 protein, human; 0/Nod2 Signaling Adaptor Protein; 0/Peptidoglycan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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