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Lessons Learned From Outbreaks of Shiga Toxin Producing Escherichia coli.
MedLine Citation:
PMID:  23212721     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
In 2011, a large outbreak caused by a Shiga toxin producing E. coli (STEC) occurred in Northern Germany, with a satellite outbreak in Western France, including the highest number of hemolytic uremic syndrome (HUS) cases ever encountered during a STEC outbreak. The outbreak strain was characterized as an enteroaggregative E. coli of serotype O104:H4 expressing a phage-encoded Shiga toxin 2. The majority of STEC infections and HUS cases were observed in adults, with a preponderance of the female gender. The outbreak imposed huge challenges on clinicians, microbiologists, and epidemiologists but also provided important new insight for the understanding of STEC infection. Thus, novel therapeutic strategies in the treatment of HUS in adults and for decolonization of long-term STEC carriers were evaluated. This review highlights the unusual features of the recent O104:H4 outbreak and focuses on emerging new strategies in diagnostics and treatment of acute STEC-related disease, as well as STEC long-term carriage.
Authors:
Susanne Hauswaldt; Martin Nitschke; Friedhelm Sayk; Werner Solbach; Johannes K-M Knobloch
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current infectious disease reports     Volume:  15     ISSN:  1523-3847     ISO Abbreviation:  Curr Infect Dis Rep     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-01-29     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  100888983     Medline TA:  Curr Infect Dis Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4-9     Citation Subset:  -    
Affiliation:
Campus Lübeck, Department of Medical Microbiology and Hygiene, University Hospital of Schleswig-Holstein, Ratzeburger Allee 160, 23538, Lübeck, Germany.
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