Document Detail

Less than 80% of absorbed iron is promptly incorporated into erythrocytes of infants.
MedLine Citation:
PMID:  10613765     Owner:  NLM     Status:  MEDLINE    
Erythrocyte incorporation of an administered iron isotope has been used as a surrogate for iron retention on the assumption (validated in normal and iron-deficient adults) that 80-100% of the retained isotope is promptly incorporated into circulating erythrocytes. This assumption has not been validated in infants or children. The purpose of our study was to determine concurrently in normal infants absorption and erythrocyte incorporation of the stable isotope, (58)Fe. In a preliminary study (Study 1), we demonstrated that fecal excretion of ingested isotope occurs predominantly during the first 4 d after administration but continues beyond 7 d after ingestion, that is, beyond the point at which isotope in feces can be explained either by excretion of isotope that failed to enter enterocytes or by exfoliation of isotope-enriched enterocytes. In Study 2, we administered (58)Fe to nine younger (age 20-69 d) and nine older (age 165-215 d) term infants and collected feces for 11 d. Geometric mean retention of (58)Fe by the younger infants was 31.2% of intake at 4 d and 26.9% at 11 d, and by the older infants, 35.0% at 4 d and 32.5% at 11 d. Erythrocyte incorporation of (58)Fe 14 d after ingestion was 5.2% of the dose by the younger infants and 12.5% by the older infants. Utilization of retained (11 d) isotope thus was 19.8% by the younger infants and 38.3% by the older infants. We conclude that far less than 80% of retained isotope is promptly incorporated into erythrocytes (utilized) by infants.
S J Fomon; E E Ziegler; R E Serfass; S E Nelson; R R Rogers; J A Frantz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  130     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-21     Completed Date:  2000-01-21     Revised Date:  2010-02-09    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-52     Citation Subset:  IM    
Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
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MeSH Terms
Aging / metabolism
Biological Availability
Erythrocytes / metabolism*
Feces / chemistry
Ferrous Compounds / administration & dosage,  pharmacokinetics*
Infant, Newborn
Iron Isotopes
Grant Support
Reg. No./Substance:
0/Ferrous Compounds; 0/Iron Isotopes; 7720-78-7/ferrous sulfate

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