| A less flexible BK channel opens more easily. | |
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MedLine Citation:
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PMID: 20620867 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BK potassium channels regulate spike width and firing rate. A BK point mutation in humans enhances channel activity, leading to epilepsy. In this issue of Neuron, Yang and colleagues use this mutation to demonstrate that channel opening is determined by the flexibility of a region that contains a Ca(2+)-binding site. |
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Authors:
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Jack Kronengold; Leonard K Kaczmarek |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Neuron Volume: 66 ISSN: 1097-4199 ISO Abbreviation: Neuron Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 817-8 Citation Subset: - |
Affiliation:
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Yale University School of Medicine, Department of Pharmacology, New Haven, CT 06520-8066, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Comments/Corrections | |
Comment On:
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Neuron. 2010 Jun 24;66(6):871-83
[PMID:
20620873
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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