Document Detail


Lesions of the ventromedial hypothalamus reduce postingestional thermogenesis.
MedLine Citation:
PMID:  9145938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this experiment was to evaluate the effects of ventromedial hypothalamus lesions on the thermogenic changes that follow food intake. Four groups of six Sprague-Dawley male rats were used. Under anesthesia with pentobarbital, the animals in the first and second groups received lesions at the ventromedial hypothalamus, and animals in the third and fourth groups received sham lesions. Body weight and food intake were monitored daily until the experimental procedure began. Twenty days after lesion, oxygen consumption, firing rate of sympathetic nerves to interscapular brown adipose tissue (IBAT), and IBAT temperature were monitored for 45 min both before and after 5 g food intake in 24 h fasted rats from the first and third groups. The same variables were measured in the animals of the second and fourth groups 50 days after receiving the lesions. Lesion placements were histologically verified. The results showed that lesions produced hyperphagia and obesity. Firing rate of nerves to IBAT, IBAT temperature, and oxygen consumption increased after food intake in sham-lesioned rats. This increase was significantly reduced by the lesion at both the 20- and 50-day time points. These findings indicate that the ventromedial hypothalamus controls postingestional activation of sympathetic discharge to IBAT. The reduction of postingestional thermogenesis could be involved in the development of obesity induced by lesion of the ventromedial hypothalamus.
Authors:
M Monda; A Sullo; B De Luca
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  61     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-22     Completed Date:  1997-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  687-91     Citation Subset:  IM    
Affiliation:
Dipartimento di Fisiologia Umana e Funzioni Biologiche Integrate Filippo Bottazzi, Seconda Università di Napoli, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue, Brown / physiology
Animals
Body Temperature Regulation / physiology*
Body Weight / physiology
Brain Mapping
Eating / physiology
Male
Oxygen Consumption / physiology
Postprandial Period / physiology*
Rats
Rats, Sprague-Dawley
Sympathetic Nervous System / physiology
Ventromedial Hypothalamic Nucleus / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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