Document Detail


Lesions of tuberomammillary nuclei induce differential polydipsic and hyperphagic effects.
MedLine Citation:
PMID:  16553793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study aimed to examine the function of the tuberomammillary complex in water and food intake of Wistar rats. The results show that lesions restricted to tuberomammillary subnuclei: caudal ventral tuberomammillary nucleus (E1), rostral ventral tuberomammillary nucleus (E2), medial ventral tuberomammillary nucleus (E3) or medial dorsal tuberomammillary nucleus (E4), induce a strong and persistent polydipsia with specific characteristics for each nucleus. Interestingly, the distribution of tuberomammillary hyperdipsia throughout the day was similar to that in non-lesioned animals, in contrast to the lack of rhythmicity observed in rats with anodic lesion to median eminence. This polydipsia appears to be independent of food intake, as food deprivation for 22 h did not significantly reduce the water intake. Finally, lesions in ventral tuberomammillary nuclei E1 and E2 induce hyperphagia, confirming a possible role for the tuberomammillary complex in food intake. This increase in food intake is not observed after lesions in medial subnuclei E3 and E4. These results are interpreted in terms of the hypothalamic systems involved in the consumption of both food and water.
Authors:
J Mahía; A Puerto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  23     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-23     Completed Date:  2006-09-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1321-31     Citation Subset:  IM    
Affiliation:
Psicobiología, Universidad de Granada, Campus de Cartuja, Granada, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Circadian Rhythm / physiology
Drinking / physiology*
Drinking Behavior / physiology*
Eating / physiology*
Hyperphagia*
Hypothalamic Area, Lateral / anatomy & histology,  pathology*,  physiology*
Random Allocation
Rats
Rats, Wistar

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