Document Detail

Lesions of the MPO or AV3V: influences on fluid intake.
MedLine Citation:
PMID:  3387488     Owner:  NLM     Status:  MEDLINE    
Electrolytic lesions in the MPO of rats had no significant effects on ad lib food and water intake, but impaired the drinking response to 1 M NaCl. Large MPO lesions also produced a persistent increase in plasma osmolality. In Experiment 2, we depleted neurons from the MPO of rats by iontophoretic application of the neurotoxin kainic acid (KA) which destroys nerve cell bodies without damage to fibers of passage. KA-induced neuron depletion in the MPO of rats significantly reduced the drinking response to 1.0 M saline, to 30% PG, and to 30 micrograms/kg isoproterenol. Ad lib water intake and drinking responses to food or water deprivation, to low concentrations (0.5 M) of hypertonic saline, to low concentrations (10% or 20%) of PG, and to systemic administration of 1.5 mg/kg angiotensin II were within the normal range. In Experiment 3, rats with electrolytic lesions that were strictly confined to the tissue immediately surrounding the wall of the anteroventral portion of the third ventricle (AV3V), without invading the MPO displayed normal ad lib food and water intake and plasma osmolality as well as drinking responses to water deprivation, hypertonic saline (0.5 or 1.0 M), angiotensin II (1.5 mg/kg) and isoproterenol (30 micrograms/kg).
M K McGowan; B Brown; S P Grossman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  42     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1988  
Date Detail:
Created Date:  1988-08-11     Completed Date:  1988-08-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  331-42     Citation Subset:  IM    
Committee on Biopsychology, University of Chicago, IL 60643.
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MeSH Terms
Brain Mapping
Cerebral Ventricles / physiology*
Ependyma / physiology*
Preoptic Area / physiology*
Water-Electrolyte Balance*
Grant Support
2 SO7 RR-7029-20/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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