Document Detail


Lesioning alters functional properties in isolated spinal cord hemisegmental networks.
MedLine Citation:
PMID:  20394805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemisegmental networks produced by longitudinal lesions of the spinal cord midline are able to generate rhythmic bursting activity. This has led to the suggestion that hemisegmental networks can independently burst in the intact spinal cord. Previous analyses in the lamprey spinal cord failed to show hemisegmental bursting in NMDA. This was subsequently attributed to the failure to wait sufficient time for NMDA-evoked hemisegmental activity to recover after being abolished by the lesion, which can take tens of minutes to hours. The reason for this delay in the onset of NMDA-evoked activity was not previously addressed. We have investigated it here by examining two hypotheses: that hemisegmental networks intrinsically burst under normal conditions but that NMDA-evoked bursting was temporarily silenced by lesion-induced transmitter release; or that lesioning altered functional properties in the hemisegment that subsequently led to the development of bursting. We found no evidence to support transmitter-induced silencing of ongoing NMDA-evoked hemisegmental activity, but did find evidence for significant changes in the cellular and synaptic properties of motor neurons and premotor excitatory interneurons in lesioned hemisegmental networks. These results thus suggest that there are lesion-induced changes in functional properties in hemisegmental networks. As the interpretation of lesion studies rests on the assumption that the functional properties of hemisegmental components are not altered, further work is needed before conclusions can be made about the function of the intact system.
Authors:
N Hoffman; D Parker
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-13
Journal Detail:
Title:  Neuroscience     Volume:  168     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-25     Completed Date:  2010-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  732-43     Citation Subset:  IM    
Copyright Information:
Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Site, Cambridge CB2 3DY, UK.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Electric Stimulation
Interneurons / physiology
Lampreys
Motor Neurons / physiology
N-Methylaspartate / pharmacology
Nerve Net / physiopathology
Spinal Cord / drug effects,  physiopathology*
Spinal Cord Injuries / physiopathology
Synapses / physiology
Chemical
Reg. No./Substance:
6384-92-5/N-Methylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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