| Lesion size following Gamma Knife treatment for functional disorders. | |
| | |
MedLine Citation:
|
PMID: 9032875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this study we investigated the reproducibility and consistency of the size of radiosurgical lesions produced for functional disorders. The T1 gadolinium-enhanced magnetic resonance (MR) images of 56 patients treated for parkinsonism, pain, or other functional diseases were used to measure 140 lesion sizes at various times after radiosurgical treatment (1-26 months, mean: 11.3 months). Only the 4-mm collimator was used to create the lesions. The maximum dose ranged from 110 to 180 Gy (mean: 145 Gy). In 42 cases (78%), one isocenter was used to create the lesion. Thirteen lesions (20%) were created with two isocenters and in 1 case, three isocenters were used. Lesions were detectable on MR images as early as 30 days after treatment. The maximum lesion volume was reached after 6-12 months and ranged from nondetectable to more than 4,000 mm3. Larger lesion volumes were strongly associated with the use of more than one isocenter. In addition, maximum doses of 160 Gy or more increased the likelihood of producing lesions larger than expected. It is therefore concluded that the use of the Gamma Knife for the treatment of functional disorders is safest when single-isocenter shots with the 4-mm collimator and a maximum dose of less than 160 Gy are used. |
| | |
Authors:
|
G M Friehs; G Norén; C Ohye; C M Duma; R Marks; J Plombon; R F Young |
Related Documents
:
|
18709525 - Xanthogranulomatous epididymitis: clinical report and immunohistochemical analysis. 11511885 - Differentiation between benign and malignant findings on mr-mammography: usefulness of ... 14992355 - Contrast-enhanced power doppler sonography in breast lesions: effect on differential di... 7244305 - Evaluation of scintillation cameras by spherical lesion detectability. 14969855 - Intraductal ultrasonography and endoscopic retrograde cholangiography in diagnosis of e... 12591705 - Chronic cystic lung disease: diagnostic accuracy of high-resolution ct in 92 patients. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Stereotactic and functional neurosurgery Volume: 66 Suppl 1 ISSN: 1011-6125 ISO Abbreviation: Stereotact Funct Neurosurg Publication Date: 1996 |
Date Detail:
|
Created Date: 1997-05-28 Completed Date: 1997-05-28 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8902881 Medline TA: Stereotact Funct Neurosurg Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 320-8 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, Brown University, Providence, R.I., USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Aged Aged, 80 and over Dose-Response Relationship, Radiation Dystonia / pathology, surgery* Female Globus Pallidus / pathology, surgery Humans Male Middle Aged Pain / pathology, surgery* Parkinson Disease / pathology, surgery* Prognosis Radiosurgery* Reproducibility of Results Retrospective Studies Sex Factors Thalamus / pathology, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Electrophysiological target localization is not required for the treatment of functional disorders.
Next Document: Stereotactic Gamma thalamotomy for the treatment of parkinsonism.