Document Detail


Lesion development in focused ultrasound surgery: a general model.
MedLine Citation:
PMID:  8059487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An analytical model has been constructed for the process of formation of thermal lesions in tissue, resulting from exposure to intense, highly focused ultrasound beams such as may be used in minimally invasive surgery. The model assumes a Gaussian approximation to beam shape in the focal region and predicts, for any such focal beam, the time delay to initiation of a lesion and the subsequent time course of growth of that lesion in lateral and axial dimensions, taking into account the effects of thermal diffusion and blood perfusion. The necessary approximations and assumptions of the model are considered. Comparison of predictions with experimentally measured data on excised pig liver indicate generally good agreement. Comparisons are also made of this theory with previously published data on exposure-time dependence of lesioning threshold intensity. Deficiencies are identified in existing practice for measuring and reporting acoustic exposures for focused ultrasound surgery, and the proposal is therefore made that a quantity that would be more satisfactory, from the viewpoints both of metrology and biophysical relevance, is the intensity spatially averaged over the area enclosed by the half-pressure-maximum contour in the focal plane, as determined under linear conditions, provisionally denoted as ISAL.
Authors:
C R Hill; I Rivens; M G Vaughan; G R ter Haar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  20     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  1994  
Date Detail:
Created Date:  1994-09-13     Completed Date:  1994-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  259-69     Citation Subset:  IM    
Affiliation:
Joint Department of Physics, Royal Marsden Hospital, Sutton, Surrey, UK.
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MeSH Terms
Descriptor/Qualifier:
Acoustics
Animals
Models, Theoretical*
Swine
Temperature
Time Factors
Ultrasonic Therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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