Document Detail


Lesion characteristics related to treatment improvement in object and action naming for patients with chronic aphasia.
MedLine Citation:
PMID:  19625076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PARTICIPANTS AND METHODS: Fifteen left hemisphere stroke patients with aphasia participated in treatments for object and/or action naming. Two raters assessed extent of lesion in 18 left hemisphere cortical and subcortical regions of interest (ROIs) on CT or MRI scans. Correlations were calculated between composite basal ganglia, anterior cortical, and posterior cortical lesion ratings, on the one hand, and both pretreatment scores and treatment change for both object and action naming, on the other hand.
RESULTS: Unexpectedly, greater anterior cortical lesion extent was highly correlated with better object and action naming scores prior to treatment and with greater improvement during treatment when partial correlations controlled for total basal ganglia lesion extent (r ranging from .730 to .858). Greater total basal ganglia lesion extent was highly correlated with worse object and action naming scores prior to treatment and with less improvement during treatment when partial correlations controlled for total anterior lesion extent (r ranging from -.623 to -.785). Correlations between degree of posterior cortical lesion and naming indices generally were not significant. No consistent differences were found between the correlations of ROI lesion ratings with object naming versus action naming scores.
CONCLUSION: Large anterior cortical lesions and intactness of the basal ganglia may both contribute to more efficient reorganization of language functions.
Authors:
Bruce R Parkinson; Anastasia Raymer; Yu-Ling Chang; David B Fitzgerald; Bruce Crosson
Related Documents :
17332986 - Tumefactive fibroinflammatory lesion of the lower extremity: a case report.
23060726 - Excision with corneoscleral lamellar keratoplasty and amniotic membrane transplantation...
21906066 - Use of strontium-90 plesiotherapy for the treatment of a lingual plasmacytoma in a dog.
1095276 - Tumors of the hand.
1131356 - Solitary choroidal metastasis from bronchial carcinoid.
19591996 - Histologic classification of specimens from women affected by superficial endometriosis...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-07-21
Journal Detail:
Title:  Brain and language     Volume:  110     ISSN:  1090-2155     ISO Abbreviation:  Brain Lang     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-10-26     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7506220     Medline TA:  Brain Lang     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-70     Citation Subset:  IM    
Affiliation:
Cincinnati VA Medical Center, Cincinnati, OH, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aphasia / pathology*,  radiography,  therapy*
Brain / pathology*,  radiography
Chronic Disease
Female
Follow-Up Studies
Humans
Language Tests
Language Therapy
Linguistics*
Magnetic Resonance Imaging
Male
Mental Processes
Middle Aged
Names
Stroke / pathology,  radiography,  therapy
Tomography, X-Ray Computed
Treatment Outcome
Grant Support
ID/Acronym/Agency:
P50 DC003888-04/DC/NIDCD NIH HHS; P50 DC03888/DC/NIDCD NIH HHS; R01 DC007387-03/DC/NIDCD NIH HHS; R01DC007387/DC/NIDCD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Long term administration of LMWH - pharmacodynamic parameters under therapeutic or prophylactic regi...
Next Document:  Gastric cancer.