| Lesion of the caudal ventrolateral medulla prevents the induction of hypertension by adenosine receptor blockade in rats. | |
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MedLine Citation:
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PMID: 16457788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The continuous infusion for 7 days of the adenosine receptor antagonist 1,3-dipropyl-8-sulfophenylxanthine (DPSPX) causes a sustained hypertension in rats, with an enhancement of sympathetic neurotransmission and activation of the renin-angiotensin system. We studied the involvement of the caudal ventrolateral medulla in the establishment of this hypertensive model by evaluating the effect of local lesioning in blood pressure (BP). Male adult Wistar rats received stereotaxic injections of 0.3 mul of saline or quinolinic acid (QA; 180 mM) in the caudal ventrolateral medulla followed by abdominal implant of minipump for infusion of saline or DPSPX (90 microg(-1) kg(-1) h(-1)). BP was measured in conscious animals every 2 days for 12 days. The sustained increase of BP (22.1 mm Hg; P < 0.001) detected in rats infused with DPSPX was reverted (6.7 mm Hg; P > 0.05) from day six onwards in animals with lesion of the lateralmost part of caudal ventrolateral medulla (VLMlat). The present results suggest that the development of hypertension induced by adenosine receptor antagonist involves the participation of the VLMlat. They further add new data as to the functional complexity of this medullary area involved in a variety of functions such as cardiovascular, respiratory, motor and pain control. |
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Authors:
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Dora Pinho; Teresa Sousa; Manuela Morato; Isaura Tavares; António Albino-Teixeira |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-02-02 |
Journal Detail:
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Title: Brain research Volume: 1073-1074 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-03-21 Completed Date: 2006-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 374-82 Citation Subset: IM |
Affiliation:
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Institute of Pharmacology and Therapeutics, Faculty of Medicine of Porto and IBMC, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Blood Pressure / drug effects Hypertension / chemically induced*, prevention & control* Male Medulla Oblongata* / injuries, pathology, physiopathology Quinolinic Acid / toxicity* Rats Rats, Wistar Receptors, Purinergic P1 / antagonists & inhibitors* Time Factors Xanthines* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Purinergic P1; 0/Xanthines; 89-00-9/Quinolinic Acid; 89073-57-4/1,3-dipropyl-8-(4-sulfophenyl)xanthine |
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