Document Detail

Leptospirosis and its pulmonary complications.
MedLine Citation:
PMID:  16268921     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to assess the incidence and factors associated with pulmonary complications of leptospirosis. METHODOLOGY: In a retrospective study, patients with a definite diagnosis of leptospirosis following a 6-week period of severe flooding in Hadyai city, Thailand, were reviewed. Pulmonary complications of leptospirosis were defined as the occurrence of respiratory symptoms and an abnormal CXR. The clinical and laboratory test results for patients with and without pulmonary complications were compared. RESULTS: Among the 157 patients with leptospirosis, eight patients had pulmonary complications. Three patients had acute renal failure (ARF) and pulmonary oedema. One patient had ARF and adult respiratory distress syndrome (ARDS). Two patients had ARF, congestive heart failure and pulmonary oedema. One patient had congestive heart failure and pulmonary oedema. One patient had only ARF. Factors associated with pulmonary complications were delayed antibiotic treatment and thrombocytopenia (platelet count < 100 x 10(9)/L). Three patients developed adult respiratory distress syndrome and one died from respiratory failure. CONCLUSIONS: Pulmonary complications and death occur in a low percentage of patients with leptospirosis. Delayed antibiotic treatment and thrombocytopenia are risk factors for the development of pulmonary involvement in leptospirosis.
Kreetha Thammakumpee; Khachornsakdi Silpapojakul; Baralee Borrirak
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  10     ISSN:  1323-7799     ISO Abbreviation:  Respirology     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-04     Completed Date:  2006-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  656-9     Citation Subset:  IM    
Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Thailand.
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MeSH Terms
Aged, 80 and over
Leptospirosis / complications*,  epidemiology,  radiography
Lung Diseases / epidemiology,  microbiology*,  radiography
Middle Aged
Respiratory Insufficiency / epidemiology,  microbiology,  radiography
Retrospective Studies
Risk Factors
Statistics, Nonparametric
Thailand / epidemiology

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