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Leptospirosis in cattle.
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MedLine Citation:
PMID:  18881488     Owner:  NLM     Status:  MEDLINE    
From abnormal milk of cows an agent has been transmitted to guinea pigs, rabbits, mice, and embryonated eggs. This agent caused a febrile reaction in guinea pigs and rabbits and an inapparent infection in mice. In early passages embryonated eggs were unaffected but later death of embryos occurred 7 days after inoculation. When blood from infected guinea pigs or chorioallantoic fluid from infected eggs was inoculated subcutaneously or intranasally into young calves, fever with albuminuria and more rarely hemoglobinuria was produced, in lactating cows the infection resembled that seen in animals with natural disease. Pen contact of normal cows and calves with infected calves resulted in inapparent infection. Autopsies showed that in addition to causing altered milk secretion, the agent damaged the kidneys and produced an interstitial nephritis. The agent was recovered from blood and milk during the febrile period and was demonstrated in the urine for periods long afterwards. Antibodies for the spirochete were found in the sera of experimental animals and of cows recovered from the natural disease. The blood of infected guinea pigs, the chorioallantoic fluid from infected eggs, and the blood or urine from experimentally infected calves yielded a culture of a spirochete which appeared identical with the infective agent in comparative tests of physical, pathogenic, and immunological properties.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  88     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1948 Sep 
Date Detail:
Created Date:  1948-12-01     Completed Date:  2008-10-16     Revised Date:  2014-08-12    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  295-308     Citation Subset:  OM    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1948, by The Rockefeller Institute for Medical Research New York
Received Day: 12 Month: 5 Year: 1948
Print publication date: Day: 1 Month: 9 Year: 1948
Volume: 88 Issue: 3
First Page: 295 Last Page: 308
ID: 2135826
PubMed Id: 18881488

James A. Baker
Ralph B. Little
From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey

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