| Leptospirosis-associated acute kidney injury. | |
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MedLine Citation:
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PMID: 21541455 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Leptospirosis is the most important zoonosis in the world. Patients are typically young men. Several factors are involved in acute kidney injury (AKI) in leptospirosis, including direct nephrotoxic action of the leptospira, hyperbilirubinemia, rhabdomyolysis and hypovolemia. The major histological findings are acute interstitial nephritis and acute tubular necrosis. Leptospirosis-induced AKI is usually nonoliguric and hypokalemic. Tubular function abnormalities precede a decline in the glomerular filtration rate, which could explain the high frequency of hypokalemia. Antibiotic treatment is efficient in the early and late and/or severe phases. For critically ill leptospirosis patients, the following measures are recommended: early and daily hemodialysis; low volume infusion (due to the risk of pulmonary hemorrhage); and lung-protective strategies. Mortality in leptospirosis-associated AKI is around 22%. |
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Authors:
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Elizabeth De Francesco Daher; Krasnalhia Lívia Soares de Abreu; Geraldo Bezerra da Silva Junior |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Volume: 32 ISSN: 2175-8239 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-5-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426946 Medline TA: J Bras Nefrol Country: - |
Other Details:
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Languages: ENG; POR Pagination: 408-415 Citation Subset: - |
Affiliation:
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Faculdade de Medicina, Universidade Federal do Ceará. |
Vernacular Title:
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Insuficiência renal aguda associada à leptospirose. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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