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Leptomeningeal melanocytosis in an adult male without large congenital nevi: a rare and atypical case of neurocutaneous melanosis.
MedLine Citation:
PMID:  21726502     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Leptomeningeal melanocytosis is a primary melanocytic lesion of the central nervous system that is characterized by diffuse melanocytic infiltration of the leptomeninges. It is seen almost exclusively in children with large congenital nevi and together the findings form a dermatologic syndrome known as neurocutaneous melanosis. We report a rare and atypical case of a 31-year-old adult male with no evident congenital melanocytic lesions who presented with neurologic symptoms and was found to have leptomeningeal melanocytosis. The brain biopsy demonstrated a conspicuous but benign-appearing melanocytic infiltrate that was discordant with the severity of the patient's symptoms. Ultimately, the patient was suspected to represent a case of forme fruste neurocutaneous melanosis. Herein the relevant clinical and histopathologic features are discussed along with a brief review of the literature.
Authors:
B J Sutton; S B Tatter; C A Stanton; R T Mott
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neuropathology     Volume:  30     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:    2011 Jul-Aug
Date Detail:
Created Date:  2011-07-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  178-82     Citation Subset:  IM    
Affiliation:
Department of Pathology, and Department of Neurosurgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
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