Document Detail

Leptomeningeal involvement in B-cell chronic lymphocytic leukemia: a case report and review of the literature.
MedLine Citation:
PMID:  25218117     Owner:  NLM     Status:  Publisher    
BACKGROUND: Central nervous system involvement is considered a rare complication of chronic lymphocytic leukemia, and so there is the risk of being overlooked.
CASE PRESENTATION: We report a case of central nervous system involvement in a 75-year-old mulatto woman with chronic lymphocytic leukemia after 5 years of follow-up and a literature review on the subject. The clinical course, treatment and outcome are described. A systematic, meticulous and comprehensive analysis of existing publications regarding chronic lymphocytic leukemia with central nervous system involvement was performed.
CONCLUSION: We concluded that central nervous system involvement of chronic lymphocytic leukemia is probably not associated with any evident risk factors. Diagnostic approach differs by institutions but often includes imaging, morphology and flow cytometry. Resolution of central nervous system symptoms can usually be accomplished with intrathecal chemotherapy or irradiation followed by systemic treatment. The recognition of this entity by clinicians could lead to early detection and treatment, resulting in better outcomes in this rare complication.
Simone Lima de Souza; Fábio Santiago; Marilza de Ribeiro-Carvalho; Adriano Arnóbio; Andréa Ribeiro Soares; Maria Helena Ornellas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-13
Journal Detail:
Title:  BMC research notes     Volume:  7     ISSN:  1756-0500     ISO Abbreviation:  BMC Res Notes     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101462768     Medline TA:  BMC Res Notes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  645     Citation Subset:  -    
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