Document Detail

Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment.
MedLine Citation:
PMID:  23251128     Owner:  NLM     Status:  Publisher    
As therapeutic options and supportive care for the treatment of neoplastic disease have improved, there has been an associated increase in the incidence of leptomeningeal disease. In this review, the clinical presentation, natural history, diagnostic evaluation, and treatment options for this often devastating sequela of solid tumors, lymphoma, and leukemia will be summarized. The therapeutic efficacy of ionizing radiation, systemic agents, and intrathecal drugs will be examined from the existing literature. Additionally the pathophysiology, which in part defines the therapeutic limitations in approaching this patient population, will be discussed in order to assist in individualized clinical decision making.
Ticiana Leal; Julie E Chang; Minesh Mehta; H Ian Robins
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Publication Detail:
Journal Detail:
Title:  Current cancer therapy reviews     Volume:  7     ISSN:  1573-3947     ISO Abbreviation:  Curr Cancer Ther Rev     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2012-12-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101253264     Medline TA:  Curr Cancer Ther Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  319-327     Citation Subset:  -    
University of Wisconsin Paul P Carbone Comprehensive Cancer Center 600 Highland Ave Madison WI, 537192.
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