Document Detail


Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta.
MedLine Citation:
PMID:  18041713     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Leptin induces MAT2A and MAT2beta expression in HepG2 cells and normal hepatocytes but is mitogenic only in HepG2 cells. Pharmacological doses of SAMe or MTA lower expression of both MAT2A and MAT2beta and interfere with leptin signaling.
Authors:
Komal Ramani; Heping Yang; Meng Xia; Ainhoa Iglesias Ara; José M Mato; Shelly C Lu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  47     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-05     Completed Date:  2008-03-11     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  521-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line, Tumor
Enzyme Induction
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Hepatocytes / cytology,  enzymology
Humans
Leptin / physiology*
Liver Neoplasms / enzymology,  pathology*
Male
Methionine Adenosyltransferase / genetics*
Mice
Mice, Inbred C57BL
RNA / genetics
RNA, Neoplasm / genetics
Grant Support
ID/Acronym/Agency:
AA12677/AA/NIAAA NIH HHS; AA13847/AA/NIAAA NIH HHS; AT1576/AT/NCCAM NIH HHS; DK48522/DK/NIDDK NIH HHS; DK51719/DK/NIDDK NIH HHS; R01 AA012677/AA/NIAAA NIH HHS; R01 AA012677-05/AA/NIAAA NIH HHS; R01 AA013847/AA/NIAAA NIH HHS; R01 AA013847-05/AA/NIAAA NIH HHS; R01 AT001576/AT/NCCAM NIH HHS; R01 AT001576-05/AT/NCCAM NIH HHS; R01 DK051719/DK/NIDDK NIH HHS; R01 DK051719-11/DK/NIDDK NIH HHS; T32 AA07578/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Leptin; 0/RNA, Neoplasm; 63231-63-0/RNA; EC 2.5.1.6/MAT2A protein, human; EC 2.5.1.6/Mat2beta protein, human; EC 2.5.1.6/Methionine Adenosyltransferase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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