Document Detail

Leptin signaling pathways in the central nervous system: interactions between neuropeptide Y and melanocortins.
MedLine Citation:
PMID:  11746228     Owner:  NLM     Status:  MEDLINE    
No other hormone has drawn more attention than leptin in recent studies on the control of appetite, body weight and obesity. This hormone is produced by adipose tissue and enters the brain via a saturable specific transport mechanism. Leptin acts in the hypothalamus to modulate food intake and heat production as well as several other neuroendocrine pathways. The mechanisms through which leptin exerts its central nervous effects are now better understood. Proopiomelanocortin- and neuropeptide Y-containing neurons in the hypothalamus have emerged as potent candidate mediators of leptin action. These two neuropeptides have been shown to exert opposing effects using different pathways. Recently, Cowley et al. (2001) described a new circuit in the regulation of neuronal activity by leptin with an interaction between these two pathways. These data add complexity to the mechanisms by which leptin achieves its effects in the central nervous system, but they also offer potential mechanisms to explain the phenomenon of leptin resistance observed in obesity.
K Rahmouni; W G Haynes
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  23     ISSN:  0265-9247     ISO Abbreviation:  Bioessays     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-01-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  England    
Other Details:
Languages:  eng     Pagination:  1095-9     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Inc.
Department of Internal Medicine, University of Iowa, Iowa City 52242, USA.
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MeSH Terms
Central Nervous System / metabolism*,  physiology
Corticotropin-Releasing Hormone / metabolism
Hypothalamus / metabolism
Leptin / metabolism*
Neurons / metabolism,  physiology
Neuropeptide Y / metabolism*
Pro-Opiomelanocortin / metabolism
Signal Transduction / physiology*
alpha-MSH / metabolism*,  physiology
Reg. No./Substance:
0/Leptin; 0/Neuropeptide Y; 581-05-5/alpha-MSH; 66796-54-1/Pro-Opiomelanocortin; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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