Document Detail


Leptin: roles and regulation in primate pregnancy.
MedLine Citation:
PMID:  12087496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leptin, a hormone produced by adipose tissue and the placenta, is enhanced in the maternal circulation throughout pregnancy in both the human and the baboon ( Papio sp.), a proven nonhuman primate model for the study of human pregnancy. The presence of both leptin and its receptor in the fetus implies a role for the polypeptide as a regulator of in utero development, although localization in the placental trophoblast may relate to autocrine and/or paracrine regulatory functions in this important endocrine tissue. Although regulatory mechanisms remain incompletely defined, it has been suggested that cross talk occurs between the fetus, placenta, and maternal adipose stores. Placental estrogen, which is present in increasing concentrations with advancing gestation, is suggested to influence leptin synthesis in a tissue- and cell type-specific fashion. In this capacity, cellular hypoxia, diabetes, and preeclampsia are conditions that appear to be intimately linked to leptin dynamics. A better understanding of regulatory mechanisms will have direct clinical significance, as leptin has been proposed to impact on those causes of human perinatal morbidity and mortality that are associated with anomalies of fetal maturity and development, general conceptus growth, trophoblast endocrinology, and placental sufficiency.
Authors:
Michael C Henson; V Daniel Castracane
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  20     ISSN:  1526-8004     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-27     Completed Date:  2002-11-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-22     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, and the Tulane National Primate Research Center, Tulane University Health Sciences Center, New Orleans, Louisiana 70112-2699, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Hypoxia
Diabetes, Gestational
Embryonic and Fetal Development
Estrogens / pharmacology
Female
Gene Expression / drug effects
Humans
Leptin / analysis,  genetics,  physiology*
Papio
Pre-Eclampsia
Pregnancy
Receptors, Cell Surface / analysis,  physiology
Receptors, Leptin
Trophoblasts / chemistry
Chemical
Reg. No./Substance:
0/Estrogens; 0/Leptin; 0/Receptors, Cell Surface; 0/Receptors, Leptin; 0/leptin receptor, human

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