Document Detail

Leptin: roles and regulation in primate pregnancy.
MedLine Citation:
PMID:  12087496     Owner:  NLM     Status:  MEDLINE    
Leptin, a hormone produced by adipose tissue and the placenta, is enhanced in the maternal circulation throughout pregnancy in both the human and the baboon ( Papio sp.), a proven nonhuman primate model for the study of human pregnancy. The presence of both leptin and its receptor in the fetus implies a role for the polypeptide as a regulator of in utero development, although localization in the placental trophoblast may relate to autocrine and/or paracrine regulatory functions in this important endocrine tissue. Although regulatory mechanisms remain incompletely defined, it has been suggested that cross talk occurs between the fetus, placenta, and maternal adipose stores. Placental estrogen, which is present in increasing concentrations with advancing gestation, is suggested to influence leptin synthesis in a tissue- and cell type-specific fashion. In this capacity, cellular hypoxia, diabetes, and preeclampsia are conditions that appear to be intimately linked to leptin dynamics. A better understanding of regulatory mechanisms will have direct clinical significance, as leptin has been proposed to impact on those causes of human perinatal morbidity and mortality that are associated with anomalies of fetal maturity and development, general conceptus growth, trophoblast endocrinology, and placental sufficiency.
Michael C Henson; V Daniel Castracane
Related Documents :
2924716 - Regulation of progesterone biosynthesis by estrogen during baboon pregnancy: placental ...
18430766 - Effects of early gestation gh administration on placental and fetal development in sheep.
18295176 - Decreased placental x-linked inhibitor of apoptosis protein in an ovine model of intrau...
9089786 - Placental weight to birthweight ratio is increased in mild gestational glucose intolera...
12728126 - Binge drinking in the preconception period and the risk of unintended pregnancy: implic...
15790726 - Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  20     ISSN:  1526-8004     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-27     Completed Date:  2002-11-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-22     Citation Subset:  IM    
Department of Obstetrics and Gynecology, and the Tulane National Primate Research Center, Tulane University Health Sciences Center, New Orleans, Louisiana 70112-2699, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Hypoxia
Diabetes, Gestational
Embryonic and Fetal Development
Estrogens / pharmacology
Gene Expression / drug effects
Leptin / analysis,  genetics,  physiology*
Receptors, Cell Surface / analysis,  physiology
Receptors, Leptin
Trophoblasts / chemistry
Reg. No./Substance:
0/Estrogens; 0/Leptin; 0/Receptors, Cell Surface; 0/Receptors, Leptin; 0/leptin receptor, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Leptin and ovarian folliculogenesis: implications for ovulation induction and ART outcomes.
Next Document:  Leptin in relation to growth and developmental processes in the fetus.