Document Detail

Leptin reverses sucrose-conditioned place preference in food-restricted rats.
MedLine Citation:
PMID:  11399316     Owner:  NLM     Status:  MEDLINE    
Previous studies have suggested that food restriction can modify performance in the conditioned place preference (CPP) paradigm. In the present study, we tested the hypotheses that food restriction would enhance the development of a CPP to low-calorie sucrose pellets and that peripheral leptin replacement in food-restricted animals would reverse this effect. Using a range of 45-mg sucrose pellets (0-15 pellets) as a reward, we observed that a significant place preference was conditioned in food-restricted, but not ad libitum-fed rats. This CPP was reversed either by treatment of food-restricted rats with the dopamine receptor antagonist alpha-flupenthixol (200 microg/kg ip) during the training protocol or by chronic subcutaneous replacement of leptin (125 microg/kg/day) that attenuated the food restriction-induced decrease of circulating leptin. We conclude that dopaminergic signaling and the fall of plasma leptin concentrations contribute to the CPP of food-restricted rats. This finding suggests that in addition to metabolic adaptations, hypoleptinemia results in behavioral adaptations during states of energy deprivation.
D P Figlewicz; M S Higgins; S B Ng-Evans; P J Havel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  73     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-11     Completed Date:  2001-08-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-34     Citation Subset:  IM    
Department of Psychology, University of Washington, Seattle, WA 98195-1525, USA.
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MeSH Terms
Appetitive Behavior / drug effects*
Brain / drug effects
Choice Behavior / drug effects*
Flupenthixol / pharmacology
Food Deprivation
Leptin / pharmacology*
Receptors, Dopamine / drug effects
Social Environment*
Sucrose / administration & dosage*
Grant Support
Reg. No./Substance:
0/Leptin; 0/Receptors, Dopamine; 2709-56-0/Flupenthixol; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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